High dose thiamine improves fatigue in multiple sclerosis
The majority of the patients with multiple sclerosis (MS) experience
fatigue. Some observations indicate that fatigue and related
manifestations concomitant with MS could be associated with an
intracellular mild thiamine deficiency. Although blood thiamine and
thiamine pyrophosphate levels were within normal limit in all the
patients, high-dose thiamine therapy administered orally or parenterally
led to an appreciable improvement of the fatigue.The administration of large quantities of thiamine was effective in
reversing the fatigue in MS, suggesting that the abnormalities in
thiamine-dependent processes could be overcome by diffusion-mediated
transport at supranormal thiamine concentrations.The Physiological Changes of MS Multiple sclerosis attacks the body’s central nervous system and can cause quite severe reactions and symptoms if not properly treated. Here are a few physiological changes of multiple sclerosis (MS) and the effect that they have on your body. Some of the most well-known symptoms of MS can include muscle weakness, vision trouble, coordination problems, memory issues and sensations of numbness. However, you might not realize just how this condition affects the body. It affects the brain and nervous system and each patient’s symptoms can be less or more severe than the next, depending on their individual condition.
A new study appearing in the latest issue of STEM CELLS Translational Medicine is the first to demonstrate that, in fact, adipose-derived stem cells donated by older people are less effective than cells from their younger counterparts.
Biogen Idec, Elan facing suits over Tysabri side effects-Allegedly failed to warn of risks
On
Aug. 28 of last year Kimberley Yout, 45, was diagnosed with a rare
brain infection that developed as a side effect of Tysabri, a drug she
took for six years to keep her MS in check. Yout’s speech became
slurred, her gait unsteady, and her future uncertain. Now, she is suing
the two companies that marketed Tysabri — Biogen Idec Inc. of Weston and
the Irish drug maker Elan Pharmaceuticals Inc. The lawsuit is one of at least a half-dozen pending in Massachusetts and federal courts in three other states. In each case, plaintiffs are seeking more than $1 million in punitive damages from Biogen Idec and Elan on behalf of patients or their families. After taking Tysabri, the patients developed progressive multifocal leukoencephalopathy, known as PML, an infection of the brain’s white matter that can cause death or severe disability. Her complaint, filed Friday, alleges they failed to adequately warn patients of the risks some face from prolonged use of Tysabri.more
Shelley Peterman Schwarz: Secrets of a positive attitude!
Sylvi MacCormac credits her diagnosis with multiple sclerosis in 1982 at the age of 21 for her decision to create music full-time.
Dispelling the misconceptions about multiple sclerosis
Cognitive functions in multiple sclerosis: impact of gray matter integrity
Evaluation of circulating osteopontin levels in an unselected cohort of
Increased remissions in multiple sclerosis (MS) during late pregnancy may result from high levels of sex steroids such as estrogen and estriol. Estrogen (E2=17β-estradiol) protects against experimental autoimmune encephalomyelitis (EAE), but the cellular basis for E2-induced protection remains unclear.
Early detection of neutralizing antibodies to interferon-beta in multiple sclerosis patients: binding antibodies predict neutralizing antibody development.
Review of the novelties presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (II).
Three men are raising money for the Multiple Sclerosis Society by attempting to walk the length of Hadrian's Wall.
The Bike MS: FedEx Rock-n-Roll Ride 2013 bike ride is in its fourth year in DeSoto County. The ride to end Multiple Sclerosis will be leaving the Landers Center ...
Chesapeake Challenge Walk raises money for MS research
Katy's muddy run for MS: Katy Hackling is gearing up to battle through thick mud, swim through lakes and run across challenging woodland to raise money for the Multiple Sclerosis Society.
Screening Mammo: Earlier is Better in Younger Women
More than two-thirds of breast cancer deaths occurred in younger women
with no history of mammography or with intervals of 2 years or more
between mammograms, a study of 7,300 breast cancer patients showed. More
than two-thirds of breast cancer deaths occurred in younger women with
no history of mammography or with intervals of 2 years or more between
mammograms. The findings support initiation of mammographic screening before age 50.
Migraine prevalence, socioeconomic status, and social causation
To determine whether the known higher prevalence of migraine in lower household (HH) income groups is explained by a higher
incidence rate or a lower remission rate.
The higher incidence of migraine in lower HH income groups is compatible
with the social causation hypothesis. Once initiated,
migraine remission is independent of HH income.
Onset and remission may have etiologically distinct causes.
Migraine and the social selection vs causation hypotheses
Choosing Wisely is an initiative of
the American Board of Internal Medicine Foundation in partnership with
Consumer Reports
and other consumer-oriented organizations to
encourage “physicians, patients and other health care stakeholders to
think and
talk about medical tests and procedures that may
be unnecessary, and in some instances cause harm.”1 The initiative's broader goal is to ensure that the right care is delivered at the right time and in the right place
Saskatchewan says multiple sclerosis liberation therapy clinical trial cancelled
For decades, the question of social selection vs social causation has been raised by public health researchers and social
scientists to explain the association between socioeconomic factors and mood disorders.
In 1960, Donald Acheson1 made the seminal observation that the global distribution of multiple sclerosis (MS) may be related to available hours of
sunshine; this observation was met with disbelief at the time.
To
determine whether brain atrophy and lesion volumes predict subsequent
10 year clinical evolution in multiple sclerosis
(MS). This large multicentre study
points to the complementary predictive value of atrophy and lesion
volumes for predicting long
term disability in MS.
Attributions and self-efficacy for physical activity in multiple sclerosis.
Self-efficacy is an important predictor of health-related physical activity in multiple sclerosis (MS). While past experiences are believed to influence efficacy beliefs, the explanations individuals provide for these experiences also may be critical.
Second line use of Fingolimod is as effective as (Tysabri) Natalizumab in a German out-patient RRMS-cohort.
Although Fingolimod is registered as a second-line drug in relapsing-remittend multiple sclerosis (RRMS) in Europe there are no clinical studies available comparing Fingolimod (FTY) and Natalizumab (N).
Which is the goal of cognitive rehabilitation in multiple sclerosis: the improvement of cognitive performance or the perception of cognitive deficits?
Comparing long-term results of PASAT and SDMT scores in relation to neuropsychological testing in multiple sclerosis
Protein array-based profiling of CSF identifies RBPJ as an autoantigen in
multiple sclerosis
Hunting for autoantibodies in multiple sclerosis
Neuroborreliosis during natalizumab treatment in multiple sclerosis
Multiple Sclerosis Appears to Originate in Different Part of Brain ...
Does robot-assisted gait training ameliorate gait abnormalities in multiple sclerosis? A pilot randomized-control trial.
Interactions of environment and genes in multiple sclerosis.
Interferon beta failure predicted by EMA criteria or isolated MRI activity in multiple sclerosis
To determine whether the known higher prevalence of migraine in lower household (HH) income groups is explained by a higher
incidence rate or a lower remission rate.
The higher incidence of migraine in lower HH income groups is compatible
with the social causation hypothesis.
Severe Disability in Patients with Relapsing-Remitting Multiple Sclerosis Is Associated with Profound Changes in the Regulation of Leptin Secretion..
Randomized controlled trial of a behavioral intervention targeting symptoms and physical activity in multiple sclerosis.
The impact of sexual dysfunction on health-related quality of life in people with multiple sclerosis
Review of the novelties presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (II)
Increased remissions in multiple sclerosis (MS) during late pregnancy may result from high levels of sex steroids such as estrogen and estriol.
Early detection of neutralizing antibodies to interferon-beta in multiple sclerosis patients: binding antibodies predict neutralizing antibody development.
To investigate whether early binding antibody (BAb) titers or different IFN-b biomarkers predict NAb evolution. BAb titers reliably predict NAbs. CXCL-10 is a promising sensitive biomarker for IFN-b response and its abrogation by anti-IFN-b antibodies.
Influence of multiple sclerosis, age and degree of disability, in the position of the contrast sensitivity curve peak.
A polymorphism in the resistin gene promoter and the risk of multiple sclerosis.
The Evaluation of the Retinal Nerve Fiber Layer in Multiple Sclerosis with Special-Domain Optical Coherence Tomography.
Y-39983, a Selective Rho-Kinase Inhibitor, Attenuates Experimental Autoimmune Encephalomyelitis via Inhibition of Demyelination.
Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology.
Discovery of peptoid ligands for anti-aquaporin 4 antibodies.
Cytomegalovirus seropositivity is negatively associated with multiple sclerosis
Randomized controlled trial of a behavioral intervention targeting symptoms and physical activity in multiple sclerosis.
Randomized controlled trial of a behavioral intervention targeting symptoms and physical activity in multiple sclerosis.
Cigarette smoking and associated risk of multiple sclerosisExposure to cigarette smoke is emerging as an environmental risk factor for multiple sclerosis (MS). We investigated the possible association between environmental tobacco smoke, its cumulative exposure, and MS risk.
Our results demonstrate that cigarette smoking is significantly associated with an increased risk for MS. The risk effects of smoking were more noticeable in male patients and at higher tobacco doses.
Quality of life and employment in persons with multiple sclerosis.
In the current study, in an effort to examine the effects of type of employment upon quality of life (QOL), employment was divided into three categories (full-time employment, part-time employment, and unemployment). Results of the study emphasize the need for the provision of quality vocational services to persons with MS. Issues such as quality vocational services, timeliness, and the importance of continued work are discussed.
The experience of being grounded: a phenomenological study of living with a wheelchair.
The purpose of this existential-phenomenological study was to investigate the experience of being in a wheelchair. It was a prelude to a pilot study examining the effect of "seated" Tai Chi. The accommodations from the ADA Act have greatly facilitated the independence for those who are disabled, yet many obstacles remain.
on.
Monoclonal Antibodies in Treatment of Multiple Sclerosis.
Post-Tysabri (natalizumab) clinical and radiological findings in a cohort of multiple sclerosis patients: 12-month follow-up.
No Differences Observed among Multiple Clinical S1P1 Receptor Agonists (Functional Antagonists) in S1P1 Receptor Down-regulation and Degradation.
Matrix metalloproteinases and their pathological upregulation in multiple sclerosis: an overview.
Standing Data Disproves Biomechanical Mechanism for Balance-Based Torso-Weighting.
Impairment of JCV-specific T-cell response by corticotherapy: effect on PML-IRIS management?
Evolution of longitudinally extensive transverse myelitis in an aquaporin-4 IgG-positive patient.
[Genetic impairments of Wnt signaling pathways in hereditary high bone mass syndrome and sclerostosis diseases].
Steroid-responsive hearing impairment in NMO-IgG/aquaporin-4-antibody-
Connexin 43 astrocytopathy linked to rapidly progressive multiple sclerosis and neuromyelitis optica.
PRISM: A Novel Research Tool to Assess the Prevalence of Pseudobulbar Affect Symptoms across Neurological Conditions.
Higher Relative Risk for Multiple Sclerosis in a Pediatric and Adolescent Diabetes Population: Analysis From DPV Data Base.
Mesenchymal stromal-cell transplants induce oligodendrocyte progenitor migration and remyelination in a chronic demyelination model.
Giant pilomatricoma in a patient with tuberous sclerosis, both diagnosed in the adult life.
On the estimation and correction of bias in local atrophy estimations using example atrophy simulations
Distribution and expression of fibroblast-specific protein chemokine CCL21 and chemokine receptor CCR7 in renal allografts.
Increased plasma interleukin-32 expression in patients with neuromyelitis optica.
JOSI CREEK, GUEST COLUMNIST: "They took my morphine cold turkey from me because i don't act normal they thought i was a drug abuser
Patti McArthur, Columnist: MY PAIN DOC FIRED ME & SENT ME BACK TO MY MS DOCTOR WHO GAVE ME SHOTOS OF BOTOX IN MY SKULL TO HELP THE MIGRAINES!
The American Academy of Neurology's Top Five Choosing Wisely recommendations
DeAnn Burgess, Lemtrada Editor: MY LEMTRADA DIARY: I saw my neuro today & he tested me! I actually had knee reflexes!!!!!!!!!!!!!
Meg Jones, Columnist: MY COLUMN THIS WEEK IS ABOUT PERSEVERANCE]" WILL GIVE YOU GOOD TEARS & HOPE FOR THE FUTURE!
Valorie Diamond, Columnist: PAIN...LIVE OR LET RULE
FRIENDS & FAMILY DON'T UNDERSTAND YOUR MS? SHARE THIS ARTICLE WITH THEM: IT WILL MAKE THEM UNDERSTAND: "The Physiological Changes of MS"
STRESS IS NOT MS'S FRIEND! 20 Scientifically-Backed Ways To De-Stress Right Now
EDUCATIONAL ACTIVITY FOR: neurologists, neurology nurses, pharmacists and other healthcare professionals involved in the treatment of patients with multiple sclerosis.
KATRINA ANN TAYLOR, COLUMNIST: I WON'T GIVE UP ON MYSELF AFTER MY HEART BREAK & LOSS
Beth Dean, News Editor & Columnist: I'M PROUD TO SAY I'M A COPAXONE GIRL
Multiple Sclerosis Appears to Originate in Different Part of Brain Than Long Believed
Biogen Idec, Elan facing suits over Tysabri PML side effects! Biogen allegedly failed to warn Multiple Sclerosis patients of risks
FOR DOCTORS ONLY: Charting Progress in MS Treatment: Initiating, Monitoring, and Switching Disease-Modifying Therapy
Kerry Galcik, Columnist, MSnewsChannel.com: THIS IS MY 1ST COLUMN! I look forward to writing as a new columnist! Sexual dysfunction has a much larger detrimental impact on mental health than severity of MS physical disability.
Yvonne Decelis, Columnist: MY TECFIDERA DIARY: MY MEMORY & PAIN PROBLEMS ARE DISAPPEARING
LAUREN PARROTT IS OUR NEWEST COLUMNIST! In 2005, at the age of 21, Lauren was an intern at Good Morning America & has over 100 videos on YouTube
GET YOUR FREE MAGAZINE NOW: The Rocky Mountain MS Center's Magazine is FREE for our readers! Click either of the 2 links below to read the Summer Issue of InforMS
PAIN Week 2013: Proposed Opioid Reduction Guideline Reduces Depression, Pain
PAIN Week 2013:FDA Restricts Long-term Opioid Use to Combat Abuse
PAIN Week 2013: Five-Step Plan Helps Patients Cope With Pain
CINDI HOPPER, COLUMNIST: One of the worst things we have to face having MS is those days when our balance is not quite right
The FDA ordered label changes for long-acting and extended-release opioids such as OxyContin, limiting approved use to severe pain that cannot be relieved with other treatments
Valorie Diamond, Columnist: MY COLUMN THIS WEEK INCLUDES A FEW TIPS THAT HELP ME DEAL WITH MS
LOTS OF MSers NEED HELP WITH COGNITION: VIDEO GAME TRAINING CAN BOOST COGNITION
April Barbosa, Columnist & Poet: MEDICAL MARIJUANA GAVE ME MY LIFE BACK BY HELPING ME BATTLE THE MS MONSTER
PAIN Week 2013: Proposed Opioid Reduction Guideline Reduces Depression, Pain
