Department of Neurology, Friedrich-Alexander University Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany, ralf.linker@uk-erlangen.de.
Abstract: Dimethyl fumarate is an orally available treatment option for relapsing-remitting multiple sclerosis (MS) in a new formulation with improved gastroenteric coating. The mode of action comprises immunomodulatory effects and an activation of nuclear (erythroid-derived 2) related factor mediated antioxidative response pathways leading to additional cytoprotective effects. In two pivotal phase III trials, dimethyl fumarate, 240 mg twice daily, reduced relapse rates by about 50 % as compared with placebo. In the DEFINE trial, progression of disability was also significantly reduced. Both trials demonstrated a significant reduction of gadolinium-enhanced lesions as well as T2 lesions on cranial MRI. The studies revealed a beneficial safety profile of dimethyl fumarate. The most prevalent side effects were transient flushing and gastrointestinal tract irritation. Dimethyl fumarate has recently been approved in the USA for the treatment of relapsing-remitting MS. The compound is a welcome addition to the immunomodulatory treatment armamentarium for MS patients and physicians alike.
Effect of textured insoles on balance and gait in people with multiple sclerosis: an exploratory trial.
Health and Social Care Institute, Teesside University, Middlesbrough, UK. Electronic address: john.dixon@tees.ac.uk
After 2 weeks of wear, there were improvements in spatio-temporal parameters of gait. However, it is unclear whether this was a placebo effect or a learning effect.
Anxiety state affects information processing speed in patients with multiple sclerosis.
Department of NEUROFARBA, University of Florence, Largo Brambilla, 3, 50134, Florence, Italy, begoret@tin.it
Changes of brain resting state functional connectivity predict the persistence of cognitive rehabilitation effects in patients with multiple sclerosis.
Changes in RS FC of cognitive-related networks helps to explain the persistence of the effects of cognitive rehabilitation after several months in relapsing-remitting multiple sclerosis patients and their improvement on depression and QoL scales.
OnabotulinumtoxinA is Effective in Patients with Urinary Incontinence due to Neurogenic Detrusor Activity Regardless of Concomitant Anticholinergic Use or Neurologic Etiology.
Department of Urology, University of Southern California Institute of Urology, 1441 Eastlake Avenue, NOR 7416, Los Angeles, CA, 90033-9178, USA, ginsberg@ccnt.usc.edu
Regardless of concomitant anticholinergic use or etiology, onabotulinumtoxinA significantly improved UI symptoms, urodynamics, and QOL in patients with UI due to NDO. OnabotulinumtoxinA was well tolerated in all groups.
Enhanced accumulation of Kir4.1 protein, but not mRNA, in a murine model of cuprizone-induced demyelination.
A Friend in Need May Not be a Friend Indeed: Role of Microglia in Neurodegenerative Diseases.
National Brain Research Centre, Manesar, Haryana-122051, India. deepakkaushiik@gmail.com.: Kaushik DK, Basu A.
Genetic and clinical characteristics of skeletal and cardiac muscle in patients with lamin A/C gene mutations.
Inflammation Markers in Multiple Sclerosis: CXCL16 Reflects and May Also Predict Disease Activity.
Serum levels of CXCL16, MMP-9, and osteoprotegerin reflect disease activity in MS, but are not affected by ω-3 fatty acid treatment. CXCL16 could be a novel biomarker and potential predictor of disease activity in MS.
The Effect of Attending Steiner Schools during Childhood on Health in Adulthood: A Multicentre Cross-Sectional Study.
The risk of most examined diseases did not differ between former Steiner school attendees and the general population after adjustment for sociodemographics, current and childhood lifestyle features, but symptom burden from some current health complaints was reported less by former Steiner school attendees. Results must be interpreted with caution since the analysis was exploratory.
High Fat Diet Exacerbates Neuroinflammation in an Animal Model of Multiple Sclerosis by Activation of the Renin Angiotensin System.
Patterns and predictors of naturally occurring change in depressive symptoms over a 30-month period in multiple sclerosis.
Depressive symptoms change over time in persons with RRMS, and the pattern of change can be predicted by modifiable and non-modifiable factors.
Reductions in neuronal peroxisomes in multiple sclerosis grey matter.
Collectively, these observations provide evidence that there is an overall reduction in peroxisomal gene expression and peroxisomal proteins in GM neurons in MS. Changes in peroxisomal function may contribute to neuronal dysfunction and degeneration in MS.
Genetic aspects of vitamin D receptor and metabolism in relation to the risk of multiple sclerosis.
Restriction genes for retroviruses influence the risk of multiple sclerosis.
Mitochondrial and nuclear genes as the cause of complex I deficiency.
[Applications of Optical Coherence Tomography (OCT) in Neuro-ophthalmology.]
Association of common variants in KIF21B and ankylosing spondylitis in a Chinese Han population: a replication study.
Internal jugular and vertebral vein volume flow in patients with clinically isolated syndrome or mild multiple sclerosis and healthy controls: results from a prospective sonographer-blinded study.
that brainstem atrophy was not recognized by our study.
