Saturday, June 28, 2014

STUDY: The changing fortunes of Tecfidera (dimethyl fumarate)

Key points of this study:
  • Dimethyl fumarate is thought to defend against oxidative stress-induced neuronal death and support myelin integrity.
  • Dimethyl fumarate has shown to reduce annual relapse rates in relapsing remitting MS compared to glatiramer acetate.
  • It may also have a positive effect on progression of disability and the number of gadolinium-enhancing lesions.
  • It is generally well tolerated, with flushing, gastro-intestinal upset, upper-respiratory tract infections and erythema/pruritis being the most common affects reported.
  • Oral administration, good tolerability and likely safety in liver and renal disease patients may make this an attractive addition to existing MS therapies.