Saturday, May 17, 2014

21 ARTICLES & STUDIES IN SATURDAY'S NEWS FOR NEUROLOGISTS, NURSES & PATIENTS! WE'VE POSTED 5,166 STUDIES & ARTICLES FOR YOU!! MORE DAILY MS NEWS THAN ANY SITE IN THE WORLD!

Half of new MS patients may soon get Biogen’s Tecfidera
Boston-based financial services group Cowen Group Inc. said Friday morning that based on patient data, Biogen Idec Inc.’s new drug, Tecfidera, may soon be getting more than half of all new multiple sclerosis patients. The Weston, Mass. biotech launched Tecfidera in March and has managed to outdo already-high expectations ever since. During its first three months on the market, the drug accounted for more than 10 percent of the Weston, Mass.-based drug company’s second-quarter revenues of $1.7 billion, which was up 21 percent year-over-year.




Therapeutic potential of cannabinoid medicines.
Cannabis was extensively used as a medicine throughout the developed world in the nineteenth century but went into decline early in the twentieth century ahead of its emergence as the most widely used illicit recreational drug later that century. This paper will then go on to review clinical research exploring the potential of cannabinoid medicines in the following indications: symptomatic relief in multiple sclerosis, chronic neuropathic pain, intractable nausea and vomiting, loss of appetite and weight in the context of cancer or AIDS, psychosis, epilepsy, addiction, and metabolic disorders.

15 ARTICLES & STUDIES IN FRIDAY'S NEWS FOR NEUROLOGISTS, NURSES & PATIENTS! WE'VE POSTED 5,166 STUDIES & ARTICLES FOR YOU!! MS HEADLINES! MORE DAILY MS NEWS THAN ANY SITE IN THE WORLD!


High risk of cardiovascular diseases after diagnosis of multiple sclerosis
We recommend careful surveillance and preventive CVDs measures among MS patients, particularly among the women.

CAMPATH (Alemtuzumab) improves contrast sensitivity in patients with relapsing-remitting multiple sclerosis 
Alemtuzumab was associated with a greater chance of improved contrast sensitivity in patients with RRMS and may delay the worsening of visual function.

JEANNINE'S COLUMN:* My first & last visit to the new nurse practitioner from HELL!

JEANNINE EVERETT
ARCHIVE EDITOR & COLUMNIST:
I've written 11 columns for you.
Click my photo on far left side
of this page to read them

I had a bad exacerbation a few weeks ago, my whole body from my chest down became numb, (arms and hands included) and after 5 calls to my neurologist I went to have an MRI and it was found I had new lesions on my spine.  At that time it was decided that I would be given 4 days of high dose solemedrol steroids at the outpatient infusion center.  I was also on antibiotics due to an UTI, which probably caused this flare as well and was in my 6th week of Tecfidera and the meds I need to take due to this new medication.  Needless to say, I was really sick.

Be patient, I am setting this story up. I take Gabapentin, Lamotrigine (both for MS pain), high doses of Vitamin D, probiotics, cranberry pills, Tecfidera, and Clonazepam for really bad anxiety.

NEUROLOGY CONVENTION IN LAS VEGAS: GREAT REPORT WITH COMPARISONS OF ALL MS TREATMENTS


Las Vegas—When the American Academy of Neurology (AAN) published its five “Choosing Wisely” recommendations earlier this year, recommendation No. 4 was the following: “Don’t prescribe interferon-β or glatiramer acetate [Copaxone, Teva] to patients with disability from progressive, nonrelapsing forms of multiple sclerosis [MS].”

ECTRIMS UPDATE #2: BIOGEN HAS 3 NEW MS TREATMENTS THEY ARE WORKING ON THAT ARE BEING PRESENTED AT ECTRIMS: THE WORLDWIDE MEETING OF NEUROLOGISTS:


Data at The ECTRIMS Meetings will be presented from across Biogen Idec’s portfolio, including:

Investigational medicines:

PLEGRIDY(pegylated interferon beta-1a): a potential new molecular entity for relapsing forms of MS in which interferon beta-1a is pegylated to extend its half-life and prolong its exposure in the body. Pegylation offers a less-frequent dosing schedule.

DACLIZUMAB HIGH-YIELD PROCESS (DAC HYP): is being developed as a once-monthly subcutaneous injection. DAC HYP is believed to target the activated immune cells that can play a key role in MS without causing general immune cell depletion. DAC HYP is being developed under a collaboration agreement with AbbVie, Inc.

Anti-LINGO-1 (BIIB033): is the first candidate being investigated for its potential to repair neurons damaged by MS.

SUNDAY RECAP: WE'VE POSTED 118 ARTICLES & STUDIES IN THE LAST WEEK FOR NEUROLOGISTS, NURSES & PATIENTS! 5,166 MS HEADLINES ARE IN OUR ARCHIVES! MORE DAILY MS NEWS THAN ANY SITE IN THE WORLD!

 Contribution of cortical and white matter lesions to cognitive impairment in multiple sclerosis


Symptom overlap in anxiety and multiple sclerosis

Cerebral white matter blood flow and energy metabolism in multiple sclerosis

Altered expression of the plasminogen activation pathway in peripheral blood mononuclear cells in multiple sclerosis: possible pathomechanism of matrix metalloproteinase activation

Assessing interactions between HLA-DRB1*15 and infectious mononucleosis on the risk of multiple sclerosis

Perceived and actual arm performance in multiple sclerosis: relationship with clinical tests according to hand dominance

Retinal nerve fiber layer thickness in benign multiple sclerosis

International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system

Pediatric onset multiple sclerosis: McDonald criteria 2010 and the contribution of spinal cord MRI

Application of the McDonald 2010 criteria for the diagnosis of multiple sclerosis in an Argentinean cohort of patients with clinically isolated syndromes

Childhood body mass index and multiple sclerosis risk: a long-term cohort study
  
High risk of cardiovascular diseases after diagnosis of multiple sclerosis


Brain Changes May Explain Stroke Risk In Migraine Sufferers

Some people who get migraines do have a slightly higher risk of stroke. And some of the brain changes identified in the study look like mini strokes. "On the MRI migraines look like very tiny strokes," Lipton tells Shots. But the people aren't having any stroke symptoms. Still, Lipton is convinced that the process is the same. "We now know it's a risk factor for these very small silent strokes," 


Migraine and structural changes in the brain: A systematic review and meta-analysis

Migraine prevalence, socioeconomic status, and social causation

Sunbathing more effective than vitamin D in preventing multiple sclerosis
A little ray of sunshine can help combat fatigue and depression and decrease the risk of multiple sclerosis, according to new findings. GETTING a regular dose of sunshine is much more effective than vitamin D at combating fatigue and depression. STUDY: Participants also reported on the length of time they spent sunbathing. It emerged that those who spent longer in the sun suffered less from fatigue and depression.

MS study targets damage affecting nerves
Dr Veronique Miron, MRC for Regenerative Medicine at the University of Edinburgh, explains that "In multiple sclerosis patients, the protective layer surrounding ..

CLICK ON "READ MORE" BELOW FOR 96 MORE STUDIES & ARTICLES

12 ARTICLES & STUDIES IN THURSDAY'S NEWS FOR NEUROLOGISTS, NURSES & PATIENTS! 5,166 MS HEADLINES ARE IN OUR ARCHIVES! MORE DAILY MS NEWS THAN ANY SITE IN THE WORLD!


Tecfidera’s Patient Share at Three Months Postlaunch Surpasses That for Aubagio and Gilenya At the Same Stage of Their Launches
Over the next six months, Tecfidera's patient share among DMT-treated RR-MS patients is anticipated to increase significantly to 16 percent. In fact, despite being the third oral DMT to reach the MS market, patient share for Tecfidera exceeds that for the first two oral DMTs for MS—Sanofi/Genzyme’s Aubagio (1 percent) and Novartis’s Gilenya (1 percent)—at the same stage of their respective launches. Current physician trial rate for Tecfidera (65 percent) beats that for Aubagio (33 percent) and Gilenya (53 percent).

Salt-Heavy Diets Can Lead to Autoimmune Diseases
Men's Journal
These ailments, which include multiple sclerosis, type 1 diabetes, inflammatory bowel disease, and psoriasis, result from an immune system gone haywire that ...

Prescription-Drug Coupons — No Such Thing as a Free Lunch
Visit nearly any official website for a brand-name drug available in the United States and, mixed in with links to prescribing and safety information, you'll find links to drug “coupons,” including copayment-assistance programs and monthly savings cards. Most offers are variations on “Why pay more? With the [drug] savings card, you can get [drug] for only $18 per prescription if eligible” or “Get a free 30-capsule trial of [drug] with your doctor's prescription and ask your doctor if [drug] is right for you.” Why do manufacturers offer drug coupons? Are they good for patients in the long run? Are they even legal?

Judy Kazakawich, Columnist: TECFIDERA MIRACLES!

I've written 6 columns for you.
Click my photo on far left side
of this page to read them

I've really noticed an improvement in all aspects of my life and I've only been on tecdifera since July 3rd. I know I'm doing better because my family notices such a change as well as many comments from my friends. For any other angels that are starting tecfidera I wish you the very best.

I've been very fortunate in that the heat doesn't bother my ms or make it worse. I'm a sun worshiper and when diagnosed I thought that might ok - but no, not for me! In fact there was a time when my legs were achy and I'd sit in the sun and the heat just soothed the pain. Also I even have pretty warm-hot baths. I've never really been able to shower because of my balance and closing my eyes just made it so much worse. So I'm a bath girl. We even tried buying shower doors for the tub but instead of falling to the right or left (which the doors would stop me) nope I've gotta fall forward or backwards. After a few terrible falls I just gave into being a bath girl.

Yvonne Decellis, Columnist: THE NUMBNESS & PAIN IN MY HANDS HAVE IMPROVED AFTER ONLY 8 DAYS OF MY BEING ON TECFIDERA

I've written 9 columns for you.
Click my photo on far left side
of this page to read them

I just wanted to give you another Tecfidera update (sorry if I am writing in too fast and too frequently with these updates. I just want to be sure to keep you posted as to the changes as I notice them and/or have them pointed out to me.)

I used to have major issues and/or problems with numbness  and pain in my hands as a residual side effect from one of the worst exacerbations I have ever had (in 1998). During this attack, my left hand and arm went almost completely numb (and I am left handed). I eventually lost a lot of feeling in both hands and after getting over the attack (with the help of seven 6-hour Immunoglobulin drips)

I lost a significant amount of feeling in both hands, particularly in the left.

Tecfidera was the best launch in the history of MS drug launches: More than 3,500 physicians have prescribed it. About 25% of Tecfidera patients were not on a prior therapy, while about 75% switched from a different disease-modifying MS therapy"



Tecfidera got off to a fast start in terms of the number of physicians who prescribed it and the number of patients who went on the treatment, Tony Kingsley, Biogen's executive vice president of global commercial operations, told IBD. More than 3,500 physicians have prescribed it. About 25% of Tecfidera patients were not on a prior therapy, while about 75% switched from a different disease-modifying MS therapy.

FREE!!! CLICK THE YELLOW LINK BELOW TO RECEIVE A MONTHLY UPDATE OF ALL OF THE HEADLINES WE POSTED DURING EACH MONTH! PLUS COLUMNS BY NEUROLOGISTS LIKE DR. TIMOTHY VOLLMER & DR. BRIAN APATOFF


CLICK HERE NOW TO RECEIVE YOUR FREE WEEKEND UPDATE

HERE'S 156 STUDIES AND ARTICLES WE POSTED FOR YOU LAST WEEK:

Sativex oro-mucosal spray
GW Pharma has submitted a phase III investigational new drug application with the  FDA to conduct a Sativex efficacy and safety clinical program to treat spasticity due to Multiple Sclerosis. Sativex has been undergoing phase III program in the US as a treatment for Cancer pain
Composed mainly of two cannabinoids including CBD (cannabidiol,) and THC (delta 9 tetrahydrocannabinol), Sativex is administered as a metered dose oro-mucosal spray.

Impact of of wheelchair use on quality of life
Are you ready for a wheelchair? It may improve your quality of life

KAYLA'S COLUMN: I'm in a bad place in my life & feel hopeless! Life has been hell lately and I needed some time to think of something to write for my Column: So here it is...

Kayla, Guest Columnist, MSnewsChannel.com

Life has been hell lately and I needed some time to think of something to write for my Column: So this is it: I broke up with my boyfriend of 5 years a week ago! I started a new MS drug Tecfidera (because I stopped tysabri last year and the betaseron plus monthly solumedrol wasn't doing anything for me, I had 5 big new lesions on my MRI in March) but the Tecfidera has made me constantly nauseated since I started it almost a month ago, and I have gained 30 pounds in the last 6 months from being on solumedrol...I also currently have a job I HATE...I am just in a really bad place in my life and just feel stuck and hopeless.

I made the decision to break up because I didn't feel like he was treating me very well and I wanted more...I've only been on the tecfidera for about a month so I have no idea if it's working yet...I hope so.

GIVE KAYLA LOTS OF LOVE & SUPPORT! PLUS ((((GOOD LUCK TECFIDERA VIBES)))) BY CLICKING HERE & MAKING A COMMENT BELOW:

A HISTORY OF PAST...CURRENT & FUTURE MS TREATMENTS: WHERE WE'VE BEEN & WHERE WE ARE NOW


Multiple Sclerosis is a disease that doesn't often find itself in the spotlight, but multiple sclerosis is quickly becoming an ailment that drugmakers are focusing their efforts on to make a quality-of-life difference for patients.

In recent years, the incidence rate of MS has been on the rise. However, one of the few tidbits of good news here is that this may be because of earlier and proper diagnosis rather than an actual increase in MS as a disease.

Friday, May 16, 2014

HERE'S 156 STUDIES & ARTICLES WE POSTED FOR YOU IN THE LAST WEEK


GW Pharma has submitted a phase III investigational new drug application with the  FDA to conduct a Sativex efficacy and safety clinical program to treat spasticity due to Multiple Sclerosis. Sativex has been undergoing phase III program in the US as a treatment for Cancer pain
Composed mainly of two cannabinoids including CBD (cannabidiol,) and THC (delta 9 tetrahydrocannabinol), Sativex is administered as a metered dose oro-mucosal spray.


 CLICK BELOW TO READ 155 ARTICLES WE POSTED IN THE LAST 7 DAYS:

MY COLUMN TODAY IS FILLED WITH TECFIDERA TIPS! I took my first 2 Tecfidera pills yesterday & my 3rd today!


Yvonne Decelis, Columnist, MSnewsChannel.com

Hi there. I wanted to share this with our MSnewsChannel.com readers!
I took my first 2 Tecfidera pills yesterday and my 3rd today. I followed the advice of eating "substantial meals" and had Kefir cultured milk probiotic smoothies about 30mins b4 each pill. I don't feel any different (it's too soon I think) but no adverse reactions whatsoever...feeling hopeful!!! Plus: I happily trashed my remaining Avonex and Sharps box! I'LL UPDATE YOU ON TECFIDERA IN MY NEXT COLUMN!

Read 10 of my articles by clicking my photo in the left Column

31 ARTICLES & STUDIES IN FRIDAY'S NEWS


Seizure Disorders Enter Medical Marijuana Debate
The role of cannabinoids in the treatment of seizure disorders in children has come under the spotlight in recent months amid a string of media reports of parents obtaining the substances in states where medical marijuana is now legal and claiming "miraculous" reductions in seizures with the treatment.

Impact of of wheelchair use on quality of life
Are you ready for a wheelchair? It may just improve your quality of life

24 NEW HEADLINES IN FRIDAY'S NEWS: BG-12, OPTIC NEURITIS, HEADACHES, TINGLING, URINARY INCONTINENCE...

Numbness and Tingling as a Symptom of Multiple Sclerosis. 
Parasthesia Can Affect Quality of Life

The fumaric acid ester BG-12: a new option in MS therapy.
Expert Rev Neurother. 2013 Aug 14. [Epub ahead of print]
Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany.

13 Early Signs & Symptoms of Multiple Sclerosis
Detecting the signs of multiple sclerosis early can help prevent its progression. Learn how to identify and respond to the symptoms of multiple sclerosis

HERE'S MONDAY'S HEADLINES PLUS 169 MORE ARTICLES & STUDIES FOR YOU THAT WE POSTED IN THE LAST 8 DAYS! MORE MS NEWS THAN ANY SITE IN THE WORLD!


 Rituximab review

IMPAIRED DECISION-MAKING AND DIFFUSION ORIENTATIONAL COMPLEXITY IN PEOPLE WITH MULTIPLE SCLEROSIS

Vitamin d: shining a light on clinical and sex specific effects in multiple sclerosis?

The relation between Vitamin D status with fatigue and depressive symptoms of multiple sclerosis.

Multiple Sclerosis Research: Chinese Medicine..Getting DMT is ...

 Mary Lahammer on living with multiple sclerosis: The feared disease a journalist lives with is no longer a death sentence.

Validity of the Dynamic Gait Index in People With Multiple Sclerosis

CLICK BELOW TO READ 162 MORE ARTICLES & STUDIES:

HERE'S MONDAY'S HEADLINES PLUS 169 MORE ARTICLES & STUDIES FOR YOU THAT WE POSTED IN THE LAST 8 DAYS! MORE MS NEWS THAN ANY SITE IN THE WORLD!


 Rituximab review

IMPAIRED DECISION-MAKING AND DIFFUSION ORIENTATIONAL COMPLEXITY IN PEOPLE WITH MULTIPLE SCLEROSIS

Vitamin d: shining a light on clinical and sex specific effects in multiple sclerosis?

The relation between Vitamin D status with fatigue and depressive symptoms of multiple sclerosis.

Multiple Sclerosis Research: Chinese Medicine..Getting DMT is ...

 Mary Lahammer on living with multiple sclerosis: The feared disease a journalist lives with is no longer a death sentence.

Validity of the Dynamic Gait Index in People With Multiple Sclerosis

CLICK BELOW TO READ 162 MORE ARTICLES & STUDIES:

HERE'S MONDAY'S HEADLINES PLUS 169 MORE HEADLINES FOR YOU IN THE LAST 8 DAYS! MORE MS NEWS THAN ANY SITE IN THE WORLD!


 Rituximab review

IMPAIRED DECISION-MAKING AND DIFFUSION ORIENTATIONAL COMPLEXITY IN PEOPLE WITH MULTIPLE SCLEROSIS

Vitamin d: shining a light on clinical and sex specific effects in multiple sclerosis?

The relation between Vitamin D status with fatigue and depressive symptoms of multiple sclerosis.

Multiple Sclerosis Research: Chinese Medicine..Getting DMT is ...

 Mary Lahammer on living with multiple sclerosis: The feared disease a journalist lives with is no longer a death sentence.

Validity of the Dynamic Gait Index in People With Multiple Sclerosis

 Longitudinal MR Imaging of Iron in Multiple Sclerosis: An Imaging Marker of Disease

Merck saw higher prices for its Rebif treatment for multiple sclerosis after it became available in a single-dose portable injector. 

A NEW CLASS OF MS DRUGS COMING SOON: protein based therapies (monoclonal antibodies) that are more target specific & cause less damage to the body. Genzyme’s Lemtrada will be among the first of these drugs to hit the market, with a recent approval in Europe

Currently existing immunomodulatory drugs that treat Multiple Sclerosis only work to treat relapse or attacks, manage symptoms, or modify the course of the disease.  These drugs have too many side effects due to their lack of target specificity. Another class of drugs, recently being developed, are protein based therapies (monoclonal antibodies or mAbs) that are more target specific and cause less damage to the body.

MY Tecfidera update PLUS: WHERE MY JOURNEY BEGAN by Judi Kazakawich, Tecdifera Columnist, MSnewsChannel.com

I live in northern Alberta, Canada and just like everyone else I was trying to make a career for myself. I was working at the hospital as a health record technician. Met my husband Vic in 1979, we married in 1982 and the bombshell came crashing down on December 17, 1985. I'll never forget that "life changing" day! I had been noticing numbness in my toes and fingers. This kept coming and going. Saw the doctor and he said (because I'd been overweight) oh your probably dieting too much, not eating well. He

TYSABRI: Elan Corporation bought out by Royalty Pharma


Recently, Elan Corporation ended the fight against bids from Royalty Pharma. Previously, Royalty Pharma had raised its all-cash offer from $5.7 billion to $6.4 billion.

I started Tecfidera (BG-12) again on Saturday-. I say again because I started it the beginning of last month and had an allergic reaction when I went up to the higher dose...

Jeannine Everet, Tecfidera Editor, MSnewsChannel.com
 ... a week after taking the lower dose for a week (that is how it works, take the 120mg for a week and then jump to the 240mg after that). Since I could not take Benadryl I had to stop.  My neurologist is now having me take the lower dose for 1 month before I step up to the higher dose.  I have said I hate medications and still do but I have heard so many good things about this drug if you can get through the side effects.  It is a drug not like the other drugs that are on the market for MS.  It works a lot like vitamin D where it tries to protect your immune system.  I have heard many people say after 3 month they feel so good so I accepted.  I am getting new

I feel Tecifidera drug is working for sure. I want to kiss my doctor; this is so smart to do this. This is my first diary about my journey with Tecifidera

Jeannine Everett, Tecifidera Editor, MSnewsChannel.com
This is my first diary of my journey about this new drug: Tecifidera.  I started it in the beginning of July but due to an allergic reaction I had to stop.  Most doctors don’t understand that I am allergic to Benadryl (yes this is true), so now I just started again on July 26, 2013.  This is my first week at 120mg.  I will be taking this

18 HEADLINES IN SATURDAY'S NEWS! 2,231 ARTICLES IN OUR ARCHIVE!

 9 people you need on your medical team

Approach may shield patients' immune system

Multiple Sclerosis and Vision Problems

TOO HIGH TO CARE: Cannabinoids Decrease the Th17 Inflammatory Autoimmune Phenotype.

22 MS HEADLINES FROM TODAY'S NEWS FOR DOCS, NURSES & PATIENTS

Multiple sclerosis death due to Tecfidera unlikely but still investigated (Video)

A news release stated a 59-year-old female hadn’t been taking Tecfidera; Biogen Idec’s new multiple sclerosis (MS) pill-form therapy, at the time of her death, but they are still investigating as she had been on the therapy for 5 ½ weeks 2 weeks prior. Side effects like nausea, diarrhea and vomiting are what had decided the cessation of the therapy and a spokeswoman for Biogen stated the patient had a “history of irritable bowel disease and recurring infections including bronchitis” Tecfidera delayed-release  capsules have surpassed Gilenya as chosen pill-form therapy in the fight against MS progression.

12 HEADLINES FROM TODAYS MS NEWS

 Higher Education Protects MS Patients From Cognitive Decline

At One Month Post-Launch, Over Half of Surveyed U.S. Neurologists Have Prescribed Biogen Idec's Tecfidera, the Third-to-Market Oral Therapy, to Their Multiple Sclerosis PatientsTecfidera's High Early Physician Trial Rate Surpasses that Observed With Novartis's Gilenya and Genzyme's Aubagio, According to a New Report 

Multiple sclerosis patient says cannabis-based drug Sativex ‘changed my life’

PR executive killed herself after taking Multiple Sclerosis drug she found online to treat her alcoholism, inquest told

CNN’s Dr. Sanjay Gupta Profiles BalanceWear® to Resolve Multiple Sclerosis Instability Issues

Evidence of delayed cancer detection in MS patients

Unraveling complex genetic interplay for MS risks

Children's firefly book helps author cope with multiple sclerosis

Teriflunomide effect on immune response to influenza vaccine in patients with multiple sclerosis

Tocopherol Derivative TFA-12 Promotes Myelin Repair in Experimental Models of Multiple Sclerosis

Negative work events and accommodations in employed multiple sclerosis patients

Underlying cause of death in Danish patients with multiple sclerosis: results from the Danish Multiple Sclerosis Registry

I'm switching from Avonex to oral Tecfidera


Yvonne Decellis, Columnist, MS News Channel

I am more than happy to "kiss" these stupid syringes goodbye.

I'm seeing my Neurologist today and he's switching me to oral Tecfidera!

I feel like I've been waiting forever for this. 

MY PHARMACEUTICAL HEAVEN: I'VE TRIED AVONEX, REBIF, BETASERON, COPAXONE, IVIG & NOW I'M GOING ON TECFEDRA

Cindi Hopper, Columnist, MSnewsChannel.com
Being diagnosed with Multiple Sclerosis is scary enough, but when they start offering all these medicine options at you and the side effects, it can be somewhat overwhelming! What you have to keep in mind is everyone is different and your body chemistry is

I really hate the heat! This heat slurs my words; it is like I am speaking another language...gives me fatigue...Bad Bowels...

(Jeannine Everett, Columnist, MS News Channel)

I hate the heat! I mean I really hate the heat.  I have to backtrack here for a bit so bear with me. I was diagnosed with MS in August of 2000 having symptoms for 14 years.  I was diagnosed with everything under the sun before this happened, Epstein Bar Syndrome, Chronic Fatigue, Ulna constriction (which I have had 3 elbow surgeries), compressed discs in my neck(2 surgeries) and Hypoglycemia.    Well anyway, I was diagnosed with MS in San Francisco (I know about this because my neurologist gave me a MSbook to help me understand what it  was) and moved to Monterey, California.  It was cold and damp.  You think hot is bad, try cold and damp.  Anyway I got this wild hair and decided to move closer to my son in Arizona.  OK, that’s a good idea because in Monterey I could never get warm (everyone thought 80 degrees was a heat wave), so Arizona would be warm and I would love it. What was I thinking #^%#(&^)^)(&_&*.

"European green light for new multiple sclerosis medicine Lemtrada (alemtuzumab) - once known as Campath"



LONDON (Reuters) Jun 10 - One of the world's longest running drug development sagas may draw to a close this month as French firm Sanofi hopes for a European green light for its new multiple sclerosis medicine Lemtrada (alemtuzumab) - once known as Campath.
After studying Lemtrada since the early 1990s, he believes the drug's infrequent infusions have a lot to offer patients.
Sanofi, too, is optimistic about a medicine that would mark its second victory in MS, following last year's U.S. approval of Aubagio, a pill. It expects an EMA verdict by mid-year, implying a decision at the agency's next expert meeting on June 24-27.

Biogen Idec Announces Enrollment of First Patient in Oral Therapy Combination Trial in Multiple Sclerosis

(Posted By: Josi Creek)


Biogen Idec today announced enrollment of the first patient in a multicenter Phase II clinical trial designed to evaluate its investigational oral therapy BG-12 (dimethyl fumarate, tecfidera) in combination with commonly used first-line treatments in patients with relapsing-remitting multiple sclerosis (RRMS). The trial, called EXPLORE, will evaluate the safety and tolerability of BG-12 when administered with beta interferons (IFNB) or glatiramer acetate (GA) to patients who continue to have evidence of disease activity despite receiving consistent monotherapy for at least a year ,



Monday, May 5, 2014

Multiple sclerosis death due to Tecfidera unlikely but still investigated (Video)

A news release stated a 59-year-old female hadn’t been taking Tecfidera; Biogen Idec’s new multiple sclerosis (MS) pill-form therapy, at the time of her death, but they are still investigating as she had been on the therapy for 5 ½ weeks 2 weeks prior. Side effects like nausea, diarrhea and vomiting are what had decided the cessation of the therapy and a spokeswoman for Biogen stated the patient had a “history of irritable bowel disease and recurring infections including bronchitis” Tecfidera delayed-release  capsules have surpassed Gilenya as chosen pill-form therapy in the fight against MS progression.

12 HEADLINES FROM TODAYS MS NEWS

 Higher Education Protects MS Patients From Cognitive Decline

At One Month Post-Launch, Over Half of Surveyed U.S. Neurologists Have Prescribed Biogen Idec's Tecfidera, the Third-to-Market Oral Therapy, to Their Multiple Sclerosis PatientsTecfidera's High Early Physician Trial Rate Surpasses that Observed With Novartis's Gilenya and Genzyme's Aubagio, According to a New Report 

Multiple sclerosis patient says cannabis-based drug Sativex ‘changed my life’

PR executive killed herself after taking Multiple Sclerosis drug she found online to treat her alcoholism, inquest told

CNN’s Dr. Sanjay Gupta Profiles BalanceWear® to Resolve Multiple Sclerosis Instability Issues

Evidence of delayed cancer detection in MS patients

Unraveling complex genetic interplay for MS risks

Children's firefly book helps author cope with multiple sclerosis

Teriflunomide effect on immune response to influenza vaccine in patients with multiple sclerosis

Tocopherol Derivative TFA-12 Promotes Myelin Repair in Experimental Models of Multiple Sclerosis

Negative work events and accommodations in employed multiple sclerosis patients

Underlying cause of death in Danish patients with multiple sclerosis: results from the Danish Multiple Sclerosis Registry

I'm switching from Avonex to oral Tecfidera


Yvonne Decellis, Columnist, MS News Channel

I am more than happy to "kiss" these stupid syringes goodbye.

I'm seeing my Neurologist today and she's switching me to oral Tecfidera!

I feel like I've been waiting forever for this.

MY PHARMACEUTICAL HEAVEN: I'VE TRIED AVONEX, REBIF, BETASERON, COPAXONE, IVIG & NOW I'M GOING ON TECFEDRA

Cindi Hopper, Columnist, MSnewsChannel.com
Being diagnosed with Multiple Sclerosis is scary enough, but when they start offering all these medicine options at you and the side effects, it can be somewhat overwhelming! What you have to keep in mind is everyone is different and your body chemistry is

I really hate the heat! This heat slurs my words; it is like I am speaking another language...gives me fatigue...Bad Bowels...

(Jeannine Everett, Columnist, MS News Channel)

I hate the heat! I mean I really hate the heat.  I have to backtrack here for a bit so bear with me. I was diagnosed with MS in August of 2000 having symptoms for 14 years.  I was diagnosed with everything under the sun before this happened, Epstein Bar Syndrome, Chronic Fatigue, Ulna constriction (which I have had 3 elbow surgeries), compressed discs in my neck(2 surgeries) and Hypoglycemia.    Well anyway, I was diagnosed with MS in San Francisco (I know about this because my neurologist gave me a MSbook to help me understand what it  was) and moved to Monterey, California.  It was cold and damp.  You think hot is bad, try cold and damp.  Anyway I got this wild hair and decided to move closer to my son in Arizona.  OK, that’s a good idea because in Monterey I could never get warm (everyone thought 80 degrees was a heat wave), so Arizona would be warm and I would love it. What was I thinking #^%#(&^)^)(&_&*.

"European green light for new multiple sclerosis medicine Lemtrada (alemtuzumab) - once known as Campath"



LONDON (Reuters) Jun 10 - One of the world's longest running drug development sagas may draw to a close this month as French firm Sanofi hopes for a European green light for its new multiple sclerosis medicine Lemtrada (alemtuzumab) - once known as Campath.
After studying Lemtrada since the early 1990s, he believes the drug's infrequent infusions have a lot to offer patients.
Sanofi, too, is optimistic about a medicine that would mark its second victory in MS, following last year's U.S. approval of Aubagio, a pill. It expects an EMA verdict by mid-year, implying a decision at the agency's next expert meeting on June 24-27.

Biogen Idec Announces Enrollment of First Patient in Oral Therapy Combination Trial in Multiple Sclerosis

(Posted By: Josi Creek)

Biogen Idec today announced enrollment of the first patient in a multicenter Phase II clinical trial designed to evaluate its investigational oral therapy BG-12 (dimethyl fumarate) in combination with commonly used first-line treatments in patients with relapsing-remitting multiple sclerosis (RRMS). The trial, called EXPLORE, will evaluate the safety and tolerability of BG-12 when administered with beta interferons (IFNB) or glatiramer acetate (GA) to patients who continue to have evidence of disease activity despite receiving consistent monotherapy for at least a year ,


Tuesday, November 26, 2013

"Tecfidera doesn't sicken me like Avonex & its helping with my MS symptoms but its helping with the Fibro pain & spasms"

WOW!! YVONNE'S TECFIDERA STORY SOUNDS LIKE A MIRACLE!!! PLEASE GIVE HER (((HUGS))) FOR SHARING THIS WITH US!!

PLUS GIVE YVONNE (((CONGRAT HUGS)))) SHE JUST DID A 2 1/2 HOUR WORKOUT! 
Hi Stan. I am making myself go workout for a few hours (2.5).

By the way - just got back - the reason I love Tecfidera is that it is a pill (not an injection) so I have my weekends back. 

Tecfidera doesn't sicken me like the Avonex used to and, not only is it helping with my MS symptoms but it also seems to be helping with the Fibro pain and spasms!! My husband agrees wholeheartedly with me about that last part. 

I had a spasm last night that lasted less than 5 minutes. They used to last for HOURS...

 

Tuesday, October 29, 2013

Biogen Idec Inc, the maker of multiple sclerosis drugs Avonex, Tysabri and Tecfidera, boosted its 2013 forecast after Tecfidera sales topped analysts’ third-quarter estimates.

Revenue this year will grow by 23 percent to 25 percent, with adjusted earnings of $8.65 to $8.85 a share, the Weston, Massachusetts-based drugmaker said today in a statement. The company previously had projected revenue gaining 22 percent to 23 percent and adjusted earnings of $8.25 to $8.50 a share.
TECFIDERA WAS DERIVED FROM AN OLD BASIC CHEMICAL: FUMERIC ACID, USED TO MAKE FOODS TASTE SOUR & TO PRESERVE THEM! 


Dimethyl fumarate has been used to prevent mold from growing on furniture during shipping from China. The chemical was implicated in cases of skin rashes in Europe, where dimethyl fumarate is now banned from consumer products.
There aren't very many drugs that are also, essentially, industrial chemicals available in railroad-car volumes...But there are a few. One is lithium carbonate, a staple of glassmaking and ceramic glazes and also the active ingredient in drugs for depression. Another is nitrous oxide, or laughing gas, for anesthesia.

Then there's Tecfidera, or dimethyl fumarate, which was approved by the Food and Drug Administration in March to treat multiple sclerosis. The twice-a-day pill from Biogen Idec was derived from an old, basic chemical: fumaric acid, used industrially to make foods taste sour and to preserve them.

Friday, October 4, 2013

ECTRIMS Congress 2013: New TECFIDERA Data Show Sustained Efficacy and Long-Term Safety in a Broad Range of Multiple Sclerosis Patients

 ECTRIMS Congress 2013
Data presented today show that TECFIDERA® (dimethyl fumarate) continues to offer consistent and strong efficacy combined with a favorable safety profile in a broad range of patients with relapsing-remitting multiple sclerosis (RRMS), including those patients who are newly diagnosed with the disease. These data were presented by Biogen Idec (NASDAQ: BIIB) at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) in Copenhagen, Denmark from 2-5 October.

“Because MS is a chronic, life-long disease, physicians and patients need to know they are taking a treatment that will offer them sustained efficacy over the long-term with a consistent safety profile”

ECTRIMS Congress 2013: Biogen covers all bases for personalised approach to MS

 ECTRIMS Congress 2013

After presenting fresh data on products old and new, Biogen Idec believes that a more personalised approach to treating multiple sclerosis is the future.

The company is making over 55 presentations at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) congress in Copenhagen and unsurprisingly data on its oral treatment Tecfidera (dimethyl fumarate) has taken centre-stage.

Interim analyses from the ENDORSE long-term extension study show that Tecfidera maintained its effect in reducing disease activity in patients treated for four years. Furthermore, no new or worsening safety signals were observed in patients who had been on the drug for up to six and a half years.

In addition, a separate analysis of the Phase III DEFINE and CONFIRM trials reveals that the drug significantly reduced MS relapses in treatment-naive patients, while delaying the overall progression of the disease.

The data is going to do no harm to Tecfidera's already-impressive sales. The drug was only launched in March in the USA (Biogen is still waiting for European approval and would not comment on when that may be) but there has been a huge uptake across the pond, notably among new MS patients.

Biogen has also been presenting fresh data on its blockbuster Tysabri (natalizumab) which showed that use of the drug beyond two years continued to  reduce disability progression and maintained very low relapse rates. Alfred Sandrock, chief medical officer, noted that the analyses also "build upon a growing body of evidence that demonstrates greater clinical benefits for people with MS when Tysabri is initiated earlier".

Data is also being presented on Biogen's investigational MS drugs, such as Plegridy (pegylated interferon beta-1a), the pegylated version of its older blockbuster Avonex and daclizumab, a once-monthly subcutaneous injection being developed with AbbVie.

ECTRIMS Congress 2013: Biogen Idec's new multiple sclerosis drug Tecfidera remained effective for patients taking the medicine for at least 4 years with no new safety problems

 ECTRIMS Congress 2013
Biogen Idec's hot-selling new multiple sclerosis drug Tecfidera remained effective for patients taking the medicine for at least four years with no new safety problems, according to interim data from a long-term study presented on Friday at ECTRIMS in Copenhagen.

In addition, there were no new or worsening safety problems observed even in patients taking Tecfidera for up to six and a half years, according to the interim analysis presented on Friday at ECTRIMS

Tecfidera, which analysts expect to eventually dominate the MS market, had sales of $192 million in its first quarter on the market - nearly triple average Wall Street expectations.

The Endorse extension study followed patients who had taken part in two pivotal Phase III trials that led to the U.S. approval of Tecfidera.

The drug maintained its ability to reduce disease activity as measured by relapses and disease progression in patients treated for four years, the interim data showed.

Patients in the extension study also experienced a low frequency of new MS brain lesions similar to what had been observed after two years.

Monday, September 23, 2013

BIOGEN HAS 3 NEW MS TREATMENTS THEY ARE WORKING ON THAT ARE BEING PRESENTED AT THE WORLDWIDE MEETING OF NEUROLOGISTS: ECTRIMS


Data at The ECTRIMS Meetings will be presented from across Biogen Idec’s portfolio, including:

Investigational medicines:

PLEGRIDY(pegylated interferon beta-1a): a potential new molecular entity for relapsing forms of MS in which interferon beta-1a is pegylated to extend its half-life and prolong its exposure in the body. Pegylation offers a less-frequent dosing schedule.

DACLIZUMAB HIGH-YIELD PROCESS (DAC HYP): is being developed as a once-monthly subcutaneous injection. DAC HYP is believed to target the activated immune cells that can play a key role in MS without causing general immune cell depletion. DAC HYP is being developed under a collaboration agreement with AbbVie, Inc.

Anti-LINGO-1 (BIIB033): is the first candidate being investigated for its potential to repair neurons damaged by MS.

Tuesday, September 17, 2013

delete With the Tecfidera $10 Co-pay Program,* you pay just $10 a month for your treatment.


Tecifera offers comprehensive insurance counseling—with help sorting through benefits, including:

Medicare—along with financial assistance programs, including a $10 Co-pay Program.* We can even provide Tecfidera for free to those who are truly in need.

With the Tecfidera $10 Co-pay Program,* you pay just $10 a month for your treatment. This program includes:

No income requirements* – most people regardless of income can enroll in the $10 Co-pay Program
No time limit – you can re-enroll every year for as long as you take Tecfidera
No waiting – your specialty pharmacy can enroll you immediately into the program so that you can get Tecfidera right away
*Co-pay details and eligibility include:

Please note that for the $10 Co-pay Program, cost per month assumes one box of Tecfidera, containing 30 days of doses. You are eligible to enroll in the $10 Co-pay Program for as long as you are treated with Tecfidera.

Federal and state laws may prevent eligibility. People covered by Medicare, Medicaid, the VA/DoD, or any other federal plans are not be eligible to enroll. In addition, some insurance providers may prevent eligibility or restrict eligibility to people with demonstrated financial need. If you are not eligible or not sure of your eligibility, please call MS ActiveSource. There are charitable programs and even a free drug program sponsored by Biogen Idec that may be able to help you with the cost.

FREE: PILL ORGANIZER



You don't have to take Tecfidera with food, but, if you do, it may help with flushing. Be sure not to crush, chew, or sprinkle Tecfidera on food. Swallow it whole and intact. If you have a bottle of Tecfidera that’s been open for more than 90 days, just throw it away.

It's important to protect Tecfidera from light. One way to do this is by storing the capsules in their original bottle. You can also keep a weekly supply of Tecfidera in the pill organizer that you’ll receive when you start Tecfidera. With individual wells for each capsule, the pill organizer can help you remember to take your Tecfidera twice a day.



Benefits of Tecfidera..(1) Reduced relapses (2)


Benefits of Tecfidera

Tecfidera was studied in 2 clinical trials involving more than 2,600 people for 2 years each. In these studies, Tecfidera was compared against a placebo, or "fake" pill. This is a standard way to measure if a drug works as expected. Based on its clinical trials, Tecfidera was approved by the FDA to treat people with relapsing forms of multiple sclerosis. Find out more about trial results by clicking the green boxes below.

Reduced relapses
Call them relapses, flare-ups, or exacerbations. They're disruptive, and the goal is to reduce them. No MS medication completely gets rid of them, but people taking Tecfidera in a 2-year study had fewer relapses compared to placebo.
  • Fewer people taking Tecfidera had relapses
  • Relapse reductions over 2 years: percentage of people
  • 27% of people taking Tecfidera experienced relapse compared with 46% of people taking placebo, making them 49% less likely to experience a relapse.
  • This means that less than 3 out of 10 people taking Tecfidera experienced a relapse
Delayed physical disability progression
People with MS tell us how important it is for them to stay as active and mobile as they possibly can. That's why we studied physical ability in people over a 2-year period. What we learned is that Tecfidera helped delay physical disability progression in people with relapsing MS
  • 38% fewer people had disability progression compared to those taking placebo over 2 years
Slowed the development of brain lesions
You don't necessarily feel brain lesions, but the fact they show up on an MRI scan means your MS has been active. We measured 3 different types of brain lesions, and for all 3 types, people taking Tecfidera had fewer lesions when compared to placebo over the 2-year study.

How does Tecfidera work?

There's so much to know about how drugs work, and scientists are learning more every day. It's not known how Tecfidera works in the body to fight relapsing MS, but here is what researchers discovered about the active ingredient in Tecfidera and what it does inside our cells.

Our bodies contain certain toxins that can cause stress on our cells. This particular type of stress is called oxidative stress and, when it builds up, it can lead to cell damage and even destroy healthy cells in different places in our bodies, such as the central nervous system (CNS). One way our bodies respond to oxidative stress is through the Nrf2 pathway. Researchers have learned that the active ingredient of Tecfidera, dimethyl fumarate, activates this pathway in our cells.

It's important to learn as much as possible about how drugs might work in the body. It can get pretty technical, and a lot is still unknown, but you can ask your doctor to help you understand. Exploring options and talking to your doctor is a positive step toward managing your relapsing MS.

Sunday, August 25, 2013

Tecfidera was the best launch in the history of MS drug launches: More than 3,500 physicians have prescribed it. About 25% of Tecfidera patients were not on a prior therapy, while about 75% switched from a different disease-modifying MS therapy"



Tecfidera got off to a fast start in terms of the number of physicians who prescribed it and the number of patients who went on the treatment, Tony Kingsley, Biogen's executive vice president of global commercial operations, told IBD. More than 3,500 physicians have prescribed it. About 25% of Tecfidera patients were not on a prior therapy, while about 75% switched from a different disease-modifying MS therapy.

THE NUMBNESS & PAIN IN MY HANDS HAVE IMPROVED AFTER ONLY 8 DAYS OF MY BEING ON TECFIDERA

Yvonne Decellis, Columnist, MSnewsChannel.com

I just wanted to give you another Tecfidera update (sorry if I am writing in too fast and too frequently with these updates. I just want to be sure to keep you posted as to the changes as I notice them and/or have them pointed out to me.)

Tecfidera makes me almost as happy as this
I used to have major issues and/or problems with numbness  and pain in my hands as a residual side effect from one of the worst exacerbations I have ever had (in 1998). During this attack, my left hand and arm went almost completely numb (and I am left handed). I eventually lost a lot of feeling in both hands and after getting over the attack (with the help of seven 6-hour Immunoglobulin drips) I lost a significant amount of feeling in both hands, particularly in the left. All I have (or HAD) been feeling in my hands is a combination of numbness and pain.

This numbness and pain combination is something I have had to learn to live with as it significantly impacted my life (I am(/was?) left-handed). I noticed a couple of days ago that this situation has improved in my hands only 8 days into being on Tecfidera (at the starter-dose level of 120mg which is only half-strength!)

Today, my husband noticed it too and he and I tried a few "experiments" (hand exercises; having me squeeze his hand as hard as I could, having me write, etc.) and confirmed that the Tecfidera really appears to have made a significant difference. I think I may reach a point where I can get my old signature back!

Tuesday, August 13, 2013

MY TECDIFERA MIRACLES...PLUS MY SUMMER-SUN & MS!

Judy Kazakawich, Columnist, MSnewsChannel.com
I've really noticed an improvement in all aspects of my life and I've only been on tecdifera since July 3rd. I know I'm doing better because my family notices such a change as well as many comments from my friends.

For any other angels that are starting tecdifera I wish you the very best.

I've been very fortunate in that the heat doesn't bother my ms or make it worse. The books all say that heat is not good for people with ms but I guess I have to be different. I've always been a sun